A retrospective analysis of the effects of CZSG on oral mucositis induced by chemotherapy in patients with malignant tumor

Abstract

The aim of this study was to quantitatively evaluate the effects of Compound Zhuye Shigao Granule (CZSG) on Oral mucositis (OM) induced by chemotherapy in patients with malignant tumor. The patients in CZSG group started taking CZSG one day before the next chemotherapy cycle (12g each time, 3 times a day for 10 days), the control group without any treatment before chemotherapy. Differences in the incidence and severity of OM between the two groups were examined statistically according to World Health Organization scale for OM. The pain sensation, xerostomia, and taste alteration were evaluated by the Common Terminology Criteria for Adverse Events v3.0 (CTCAE). And the median duration of OM were also recorded between the two groups. There was a significant difference in the OM incidence between the control group and the CZSG group (P<0.01). All the accompanying symptom pain, xerostomia, and taste alteration differed between the two groups (P<0.0001). And the median duration of OM was significantly reduced in the CZSG group as compared to the control group (P<0.0001). Therefore our results show that CZSG has the advantage of rapid onset, good safety and few side effects in the prevention and treatment of OM induced by chemotherapy.