A practical and simplified management approach of multiple myeloma for primary healthcare specialist

Abstract

Significant progress has been made in the pathophysiological understanding, diagnosis and
management of multiple myeloma. Therapeutic indications have become more and more codified
taking into account a set of clinical and paraclinical parameters currently considered to be the most
closely correlated to the prognosis of the disease. In terms of treatment, the triphasic approach
based on induction, consolidation and maintenance is actually the gold standard. Autologous
stem cell transplantation also remains systematic in eligible patients even in the era of new highly
innovative and effective treatment. Finally, residual disease, one of the most powerful predictors of
post-treatment evolution, is becoming increasingly important and will be most likely an integral part
of the response criteria.