The protective role of valsartan in the myocardial injury of diabetic rats induced by herceptin

Authors

  • Yuetao Xie Cardiovascular Department, Hebei General Hospital, Shi Jiazhuang, Hebei Province, China
  • Jinli Zhang Cardiovascular Department, The Fourth Hospital of Hebei Medical University, Shi Jiazhuang, Hebei Province, China
  • Guang Liu Cardiovascular Department, The Fourth Hospital of Hebei Medical University, Shi Jiazhuang, Hebei Province, China

Keywords:

valsartan, herceptin, diabetes mellitus, angiotensin, myocardial injury

Abstract

Objective: To evaluate the protective role of valsartan in the myocardial injury of diabetic rats induced
by herceptin.

Method: 40 Sprague Dawley (SD) rats were randomly divided into control group and treatment group,
20 in each group. All the rats were faded with high sugar and high fat diet in 4 weeks, and then were given
streptozotocin (STZ) by intraperitoneal injection in dose of 25mg/kg, fasting blood glucose (FBG) ≥
16.7mmol/L as a standard of type 2 diabetes model. Two groups were given herceptin by intraperitoneal
injection, 12mg/kg in the first day and then 6mg/kg in the following 6 days, but the treatment group
was given valsartan by gavage before herceptin injection in dose of 10mg/kg one day, the control group
was given the same dose of saline by gavage. The serum BNP were measured, echocardiogram was
performed to evaluate the cardiac function before herceptin injection and after 4 weeks.

Results: After 4 weeks the BNP, LVEDD, LVESD of the control group were larger than the treatment
group, and the EF were smaller, and they were statistically different.

Conclusion: Valsartan can alleviate myocardial injury diabetic rats induced by herceptin.

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Published

2021-08-11

Issue

Vol. 1 No. 3

Section

Articles