Potential Clinical Usefulness of CRISPR/Cas9 Genome Editing in Cancer Treatment

Authors

  • Marjan Assefi Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  • Sahar Asvadi Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  • Hossein Ghahramani Almanghadim Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  • Fatemeh Zeinali Sehrig Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  • Zahra Foruzandeh Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  • Shahab Masoumi University of California, Berkeley, Berkeley, USA
  • Hadis Sheikhi University of North Carolina at Greensboro, Greensboro, North Carolina , USA

Abstract

Cancer is still considered a main challenge regarding morbidity and mortality, although an earlier
diagnosis through screening programs and more effective cure modalities have led to decreased mortality
rates so the development of new genetic editing techniques such as zinc finger and TALENs or CRISPRCas9
has enabled the production of strong animal genetic models that sums up the cooperating oncogenic
lesions influencing genes with a confirmed role in the proliferation and formation. This review presents
the mechanisms of separate genome-editing approaches and explains each of the common nucleasebased
platforms.

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Published

2021-07-18

Issue

Vol. 1 No. 2

Section

Articles