Comparison of the major chemical constituents and antioxidant effects in Amauroderma rugosum and Ganoderma lucidum

Abstract

Aging is a major risk factor for many diseases, including cardiovascular diseases, neurological disorders,
cancer and diabetes mellitus. Oxidative stress plays a key role in the aging process. Amauroderma
rugosum is an edible mushroom that has rarely been studied. The aims of this study were to compare
the major chemical constituents and to investigate the antioxidant effects of Amauroderma lucidum
and Ganoderma lucidum. The water extract of Amauroderma lucidum contained a higher amount of
total phenolic compounds than that of Ganoderma lucidum. The total polysaccharide and triterpene
content in water extracts of Amauroderma rugosum and Ganoderma lucidum did not significantly differ.
The water extract of Amauroderma rugosum demonstrated free radical scavenging capacity and could
reduce doxorubicin-induced damage in H9c2 cardiomyoblasts. Amauroderma rugosum has stronger
antioxidant and cellular protective effects than Ganoderma lucidum. Amauroderma rugosum may be
beneficial in healthy aging, and further study should be encouraged.