The Matryoshka code of COVID-19 mRNA vaccines: overlapping viral sequences?

Abstract

We read with great interest the paper by
Beaudoin CA et al. “Are There Hidden
Genes in DNA/RNA Vaccines?”, reporting
overlapping sequences between the SARSCoV-
2 spike (S) glycoprotein and two viral
genes [1]. If translated, the undesired proteins
may cause rare, untoward effects, including
those recorded in Vaccine Adverse Event
Reporting System (VAERS).
These findings are in line with our own
research and that of others however, aside
from overlapping genes (OLGs), the S
protein also contains overlapping molecular
structures and signals (heptad repeats, simple
sequence repeats, calcium calmodulin kinase
II, and prion-like domains) that can lead to
VAERS-recorded pathology [2-6].
Overlapping genetic and structural
information are important to viruses, as they
maximize the number of translated proteins
derived from the same genetic information
[7]. This compact arrangement also allows
for the emergence of mutations without major
genetic restructuring [8]. Furthermore, there
is evidence that such structures also regulate
gene expression in many viruses [9], including
coronaviruses [10,11](Figure 1).
Taking the above viral-derived
complication into account, messenger RNA
(mRNA) vaccines encode the full-length S
protein that when expressed on the surface of
cells, prompts the generation of neutralizing
antibodies [12]. Thus, both OLGs and
molecular systems may be translated too,
contributing to vaccine complications and
potential adverse effects.