Huangqi-Guizhi-Wuwu Decoction in the Treatment of Diabetic Nephropathy (CKD2-4): A Study Protocol for a Prospective, Open, Multicenter and Controlled Trail

Authors

  • Lu Liu College of Integrated Chinese and Western Medicine, Dalian Medical University, Dalian, China
  • Yu Xue College of Integrated Chinese and Western Medicine, Dalian Medical University, Dalian, China
  • Yang-jianing Zhao College of Integrated Chinese and Western Medicine, Dalian Medical University, Dalian, China
  • Jian-Guo Xie College of Integrated Chinese and Western Medicine, Dalian Medical University, Dalian, China
  • Qing Guan College of Integrated Chinese and Western Medicine, Dalian Medical University, Dalian, China
  • Yue Zhou The First Affiliated Hospital, Dalian Medical University, Dalian, China
  • Jing-Chun Pan College of Integrated Chinese and Western Medicine, Dalian Medical University, Dalian, China
  • Chang-Chuan Bai Dalian Hospital of Traditional Chinese Medicine, Dalian, China
  • Da-Peng Wang Department of Nephrology, The First Affiliated Hospital, Dalian Medical University, Dalian, China

Keywords:

clinical research；diabetic nephropathy；control study

Abstract

Background: In recent years, the disease spectrum has been changing with the change of people's
lifestyle. In terms of kidney diseases, the incidence of diabetic nephropathy is increasing year by year
and has replaced chronic glomerulonephritis as the primary cause of uremia. Therefore, it is important
to delay the progression of renal function in patients with diabetic nephropathy to reduce the occurrence
of uremia.

Objective: To investigate the efficacy of the treatment of diabetic nephropathy (CKD2-4) with the
addition and subtraction of Huangqi-Guizhi-Wuwu Decoction.

Method: The 100 patients with diabetic nephropathy were divided into two groups to compare the
clinical efficacy. The control group was basic treatment + dapagliflozin, and the observation group was
treated with Huangqi-Guizhi-Wuwu Decoction to compare the clinical efficacy, traditional Chinese
Medicine (TCM) syndrome integral change, creatinine and urinary protein quantification of the two
groups.

Expected results: Compared with the dapagliflozin, the addition and subtraction of Huangqi-Guizhi-
Wuwu Decoction can significantly reduce the glomerular filtration rate, lower proteinuria of diabetic
nephropathy (CKD2-4) and delay the progression of diabetic nephropathy.

Downloads

Published

2022-07-31

Issue

Vol. 2 No. 2

Section

Articles