Role of Melatonin in Curtailing Oxidative Stress during COVID-19

Abstract

Several studies carried out during the ongoing COVID-19 pandemic revealed that oxidation stress is a major factor in the disease development, particularly in its severe complications, such as ALI and ARDS. It has been hypothesized that the well-known natural hormone melatonin may play a significant role in countering oxidative stress and consequently easing the progression of COVID-19. The present review summarizes available information on the contribution of oxidation stress during the pathogenesis of COVID-19 and several other diseases, and the rationale of their possible treatment with melatonin. This research direction will further expand our knowledge about melatonin beyond its role as the regulator of the circadian rhythm, and towards its application as an efficient adjuvant treatment for various diseases, including COVID-19 infection.