The Japan Journal of Research (ISSN 2690-8077) is a dynamic open-access, peer-reviewed multidisciplinary natural science journal. Our mission is to offer a prominent platform for disseminating research findings across a diverse range of academic disciplines and to share knowledge globally. Our journal serves as a valuable resource for researchers, students, and anyone with a strong interest in staying updated on original research and developments in their respective fields. We welcome articles from various domains, including: Health Sciences: Medicine, Dentistry, Nursing, Pharmacy, Toxicology, Veterinary Science, Psychology, and more. Life Sciences: Biology, Agriculture, Microbiology, Virology, Neuroscience, Biochemistry, Genetics, and more. Physical Sciences & Engineering: Chemistry, Engineering, Environmental Science, Physics, Computer Science, Energy, Astronomy, Mathematics, Material Science, Industrial Research, and beyond. Social Sciences: Arts & Humanities, Economics, Business, and related disciplines. Our journal accepts a wide array of article types, such as research papers, reviews, mini-reviews, case reports, letters to the editor, commentaries, and reports, fostering a comprehensive platform for scholarly discourse. We uphold rigorous double-blind peer-review processes to ensure impartial evaluation of submissions. Once accepted, all articles are promptly accessible online at no cost. You can easily submit your manuscripts through our user-friendly online portal or by directly emailing them as attachments to the editorial office at publications@scienceexcel.org Join us in the quest for knowledge and innovation as we continue to facilitate the exchange of cutting-edge research and insights.
The Efficacy of Smooth Vergence and Jump Convergence in Vision Therapy
Binocular vision disorders, particularly convergence insufficiency, are prevalent conditions that significantly impact visual comfort and performance during near tasks such as reading and screen use. Vision therapy, a non-invasive intervention aimed at improving visual efficiency and coordination, plays a central role in the management of such disorders. Two of the most widely used approaches in vergence training—smooth vergence and jump convergence exercises—target different aspects of the fusional vergence system. Smooth vergence emphasizes sustained, gradual changes in vergence demand, improving alignment endurance and amplitude, while jump convergence involves rapid shifts in focus to enhance vergence facility and responsiveness. This review article examines the definitions, principles, and clinical techniques associated with both training modalities, including tools such as vectograms, stereoscopes, aperture rules, and free-space fusion cards. A comprehensive synthesis of the literature reveals strong evidence supporting the efficacy of both smooth and jump vergence exercises in reducing symptoms and improving clinical outcomes in individuals with convergence insufficiency and related binocular vision anomalies. Studies also indicate their value in specialized populations, such as children with learning-related visual problems, adults experiencing digital eye strain, and athletes requiring dynamic visual coordination.In addition to comparing therapeutic outcomes and mechanisms of action, this review explores the clinical implications of integrating both techniques into customized vision therapy protocols. The article concludes with recommendations for future research, including the standardization of training regimens and the development of technology-assisted delivery methods. By highlighting current evidence and practical applications, this review supports the continued use and evolution of vergence therapy as an effective treatment for binocular vision dysfunctions.
Copyright (c) 2025 Japan Journal of Research
Design and Implementation of a Training Program for Hands-On Lithium-Ion Battery Testing in Automotive Engineering Education
The rapid transition from conventional internal combustion engines to electrified vehicles has revolutionized the automotive industry, demanding significant upskilling of the current and future automotive workforce. Among the most critical components of electrified vehicles is the lithium-ion battery, whose performance, safety, and lifetime directly impact vehicle efficiency, reliability, and cost. To address this challenge, this study proposes a comprehensive, hands-on training program to equip automotive engineers with practical skills in lithium-ion battery testing and data interpretation. Seven fundamental battery tests are integrated into the curriculum: continuous constant current discharging tests across different C-rates, discharging tests under varying ambient temperatures, surface temperature distribution measurements, open-circuit voltage vs. state-of-charge profiling, internal resistance measurements, battery aging studies, and internal short-circuit experiments. This article discusses in detail the experimental methods, instrumentation, procedures, and key observations of each test. The proposed program aims to bridge the knowledge gap between theoretical concepts and real-world applications, enabling engineers to design, analyze, and diagnose lithium-ion batteries effectively for next-generation hybrid and electric vehicles
Effect of Tillage System, Herbicide Weed Management, and N-Split Application on Yield and Milling Quality of Irrigated Rice (Oryza Sativa L.) in the Guinea Savannah Zone of Ghana
In the Guinea Savannah agro-ecological zone of Ghana, rice productivity is hampered by suboptimal tillage practices, ineffective weed management, and poor soil fertility. To address these constraints, a field experiment was carried out in Botanga and Golinga to evaluate the effects of tillage systems, herbicide application methods, and N-split fertilizer regimens on irrigated rice (Oryza sativa L.) yield and milling quality. The study used a 3 x 3 x 3 factorial design arranged in a split-split-plot with three replications. Results revealed that soils at both sites were clay loam, slightly acidic (pH 5.10), with low total nitrogen (0.10%), available phosphorus (2.88 mg/kg), and exchangeable cations. Amon the treatments, minimum tillage combined with pendimethalin + triclopyr significantly reduced weed density compared to other combinations. The application of pendimethalin (0.40 kg a.i. ha⁻¹) + triclopyr (0.03 kg a.i. ha⁻¹), coupled with 120 kg N ha⁻¹ split into four applications, enhanced tillering (19 and 17 tillers per hill at Golinga and Botanga, respectively, at 6 weeks after planting). This treatment also produced the highest filled spikelets per panicle and maximum 1000-grain weight at both locations. The same fertilizer and herbicide combination yielded the highest grain production, 8,487 kg/ha at Golinga and 8,016 kg/ha at Botanga, and showed positive correlations with panicle weight, seeds per panicle, and straw weight. Additionally, it resulted in the highest unbroken grain recovery (7.5 mm) and benefit-to-cost ratio. The study recommends applying pendimethalin + triclopyr at 0.40 kg a.i. ha⁻¹ combined with 120 kg N ha⁻¹ split into four doses to maximize rice yield, quality, and income. Overall, the research underscores the significance of tailored, evidence-based agronomic practices to improve rice productivity in Ghana’s Guinea savannah zone.
Research on the Dynamic Mechanism of Cruise Industry Chain Synergy Development Based on Value Chain
The cruise industry in China has experienced relatively slow growth compared to the global market, despite its increasing economic importance. This study aims to explore a more efficient mechanism for the synergistic development of the cruise industry chain in China by constructing a system dynamics model. The model evaluates the upstream, midstream, and downstream segments of the cruise value chain and examines the causal relationships among value nodes. By assessing the characteristics and inter-connections of each segment, the study qualitatively analyzes the synergies within the chain and develops a framework for collaborative development. Vensim software is employed to simulate the cruise industry’s evolution in Shanghai, identifying the main factors influencing synergy across the chain. The findings offer theoretical and methodological guidance for enhancing coordination across industry sectors and improving policy-making. This paper contributes original insights into the interactions between different segments of the cruise industry chain and proposes a dynamic model for fostering collaborative growth. By quantifying interdependencies and simulating their economic impacts, the research provides actionable strategies to support integrated development. The proposed model supports strategic planning, enhances value creation, and lays the groundwork for more cohesive growth within China’s cruise industry.
A mild oxidative stress could modulate the Nrf2 pathway in CoVid-19 patients
Due to the technical difficult in built up a stable vaccine against some viruses whose structure change with multiple mutations, the possibility of overcoming the problem could be an indirect approach. As proposed by some authors, the system medicine science suggests the possibility to act counteracting the mechanism induced by the pathogen rather than acts directly against the virus exploiting the hormesis phenomenon. Indeed, most of the COVID-19 fatalities are a consequence of the cytokine storm because of the strong oxidative stress and inflammation induced by an exaggerated response of the immune system. While a vaccine is addressed to simulate the image of the virus and to induce a humoral protection, the indirect approach trough a mild oxidative stress simulates the effect induced by the virus itself promoting the activation of defence mechanisms which in turn could favor the healing of the patients..
Logical Beauty Harmony and Natural Shape zones (NSz)
The effect of multidisciplinary teamwork on nutritional intervention in patients with pulmonary arterial hypertension
Objective: To explore the effect of multidisciplinary teamwork of nutritional intervention in patients with pulmonary arterial hypertension (PAH). Methods: Multidisciplinary teamwork of nutrition management for patients with PAH was established. 100 patients with nutritional risk of PAH were randomly divided into control group and intervention group. The control group was given routine nutritional support, while the intervention group, was given the multi-team nutritional management scheme for nutritional intervention. After 4 weeks, the nutritional parameters, clinical symptoms, biochemical parameters and disease prognosis of the two groups were compared. Results: Compared with the control group, the total score of nutritional risk screening was significantly reduced in the intervention group after 4 weeks. Serum albumin, the value of PaCO2 and the 6min walking distance were significantly increased, but the Brog dyspnea grade was significantly decreased (P<0.05). Conclusion: The multidisciplinary teamwork applied to nutritional intervention in patients with PAH can effectively reduce the incidence of nutritional risk, improve the immunity of body, relieve clinical symptoms such as dyspnea, improve patient’s endurance and reduce fatality rate
Real-world experience with Tocilizumab for the treatment of COVID-19: a retrospective series of 314 patients
Background: In December 2019, a novel coronavirus, SARS-CoV-2, caused an outbreak of pneumonia that spread worldwide triggering the worst pandemic in recent history. Some patients with COVID-19 developed a hyperinflammatory syndrome resulting in acute respiratory distress syndrome with high mortality. We report our experience with tocilizumab (TCZ) for the treatment of patients with acute respiratory failure in the context of COVID-19 severe pneumonia. Methods: We performed a retrospective study including the patients treated with Tocilizumab from March 11 to April 30 2020 in HM Hospitals in Madrid, Spain. Results: We identified 314 patients treated with TCZ in our institution. The mean age was 64.9 ± 12.4 (24.1 - 91.4) and most patients were male (79.1%). One week after TCZ infusion, 75% of patients had improved in terms of oxygen intake and 25.6% did not need further oxygen therapy. Prior to TCZ administration, most patients had elevated levels of CRP, ferritin and D-Dimer. CRP levels rapidly ameliorated after TCZ infusion. Median D-Dimer increased after TCZ, more importantly in non-survivor patients. Median duration of hospitalization was 13.5 days (range 2-96; IQR 10-22). Seventy-two patients (22.9%) died. Sixty-four patients (20.4%) were admitted to the Intensive Care Unit (ICU), twenty-six of which died. Conclusions: Tocilizumab seems to be effective decreasing inflammation parameters, improving the respiratory condition and reducing mortality of severe patients. Randomized clinical trials will provide further data to evaluate the effectiveness of this promising therapy.
Radiological technologists’ self-assessment of professional competence in Japan. A survey study
The competence of radiographers is a prerequisite for guaranteeing high patient safety and quality of care. The purpose of the study was to describe the clinically active Radiological Technologists' professional competence in diagnostic radiological activities in Japan. Method was a questionnaire study with the measuring instrument Radiographers' Competence Scale which consists of two domains: "Nurse-initiated care" and "Technical and radiographic processes". Each competence was estimated based on the level and frequency of use. The study was conducted at three different hospitals with a total of 76 respondents. Analysis was done through the statistics program SPSS. The competence with the highest rated level was ‘Responsibility for preparing the medico-technical equipment’, the lowest rated was ‘Guiding the patient’s relatives’. The highest rated frequency was ‘Producing accurate and correct images’, the lowest was 'Guiding the patient's relatives'. In summary, the study opens up new doors for the exchange of competence at both international and national level.
Adequate use of biostatistics in biopharmacy and clinical studies: Critical elements and types of products studied
Background: Biostatistics are often used incorrectly in clinical studies of different types of products such as drugs, medical devices or dietary supplements. The safety and efficacy of the studied products is affected by such inappropriate use of biostatistics. Methods: This analysis is a review of several studies, showing the risks of using biostatistics incorrectly, as well as the misinterpretation of the data that may occur. The proper proceedings in the pre-study phase and post-study analytical phase are presented. Conclusions: These elements have major impacts on the development of clinical trials, regardless of the type of product investigated.
Would it be possible to be working with scientific research and not publish papers?
Scientific work is generally evaluated by scientific publications. The comparison between different working groups, therefore, can often be performed based on criteria such as number of publications and quality of journals. A relatively obsessive behavior for the next paper may be a consequence of this panorama. This article presents the opinion of the authors about the real importance of publishing papers within the scientific research process. Some comments on the stages of the research process are derived from concepts present in the literature related to the design process. Even though the research and design processes are different in objectives and methods, this comparison allows us to understand the fundamental importance of scientific publications. Scientific papers make public the information that must be absorbed, matured, reproduced, proved by the scientific community.
Comparative dosimetric analysis of the left breast carcinoma radiotherapy irradiation techniques with deep inspiration breathing and free breathing
Breast cancer (BC) is the second most common malignancy in the world, most commonly diagnosed in women. Radiotherapy (RT) for left breast cancer (LBC) is followed by a higher incidence of ischemic heart disease and an increased risk of death. Radiotherapy was applied for 76 patients with LBC using tangential 3D conformal RT (3D CRT) with two different radiotherapy techniques - free breathing (FB) and deep inspiration breath-hold (DIBH). The patients were treated in the period 2016 - 2019 in the Oncology Center, Uni Hospital, Panagyurishte, Bulgaria. We present a comparative dosimetric analysis of the mean heart dose (MHD), mean and maximum left anterior descending (LAD) coronary artery doses and mean and maximum left ventricle doses reported with two different radiotherapy techniques FB and DIBH. The linear regression statistical analysis shows a significant decrease in the MHD with the DIBH technique. The left breast cancer RT with the DIBH technique significantly reduces the mean heart dose and allows controlling the maximum LAD dose and the maximum ventricle dose.
Lactobacillus fermentum ME-3 – a probiotic with potential for anti-atherogenic, anti-oxidative and anti-diabetic application
Growth and sweetener content in Stevia rebaudiana Bert. biofertilized with Rhizophagus intraradices (Schenck & Sm.) Walker ted & Schüßler, and Azospirillum brasilense Tarrand, Krieg & Döbereiner in a substrate with bovine manure added
Growth and sweetener content were evaluated in Stevia rebaudiana Bert. cv. Morita 2, biofertilized with Rhizophagus intraradices and Azospirillum brasilense in substrates (soil + sand (1: 1 v / v), and soil + bovine manure (0.70: 0.30 v / v) in nursery. 4 g of each biofertilizer were applied to the transplant in the bottom of the hole A. brasilense in a concentration of 9 x 106 bacteria g-1 and R. intraradices 40 spores g-1 of soil and 95% colonization in a completely randomized design and six replications, microorganisms and substrates were combined, with Morpho-physiological variables of yield, final content of N, P, sweeteners and colonization of roots at 60, 90 and 120 days. The largest initial growth was in soil plus bovine manure, while R. intraradices and A. brasilense induced a greater increase. in the morpho-physiological yields at 120 days, also registering a higher proportion of sweetener, N and P.
Growth hormone and aging: focus on healthspan
The Real Mechanism of Action of Cyclophosphamide and Other Oxazaphosphorine Cytostatics
Existence and Uniqueness of Limit Cycles for a Class of Nonlinear Systems
Applying the theory of limit cycles and bifurcation of the plane autonomous system, we study the existence and uniqueness of limit cycles for a class of nonlinear systems with general significance. By using the conclusions obtained, some known results are extended and improved
Urban Green and Citizens: Complicated Relationship
Clinical-Laboratory Evaluation of a Group of Patients with Hashimoto Thyroiditis
Chronic lymphocytic thyroiditis (or chronic thyroiditis, or Hashimoto thyroiditis - HT) was first described in 1992 in Germany by the Japanese pathologist Hakuru Hashimoto as a new disease called lymphomatous struma. Today it represents the most frequent cause of hypothyroidism and goiter in the US and in areas of iodine sufficiency. It is the main cause of goiter in children and young adults and of idiopathic mixedema. The most important auto antibodies are antithyroglobulin (Anti-TG), antithyroperoxidase (Anti-TPO) and TSH receptor antibody blocker (TRAB). In the initial phase Anti-TG is markedly elevated while Anti-TPO is only mildly elevated. Anti-TG may disappear, but Anti-TPO continues to be positive for many years. Its pathogenesis has not been fully clarified. The estimate is that the pathogenesis of this immune disease is due genetic factors in 70 to 80% of cases and to environmental factors in 20 to 30% of cases. The study was conducted on 399 patients, 336 women (87.2%) and 63 men (12.8 %), ranging in age from 11 to 95 years. The predominant age ranges were 20 to 70 years for women and 30 to 60 years for men. Blood samples were obtained for the determination of TSH, T4L, T3L, thyroglobulin, and anti-TPO, anti-thyroglobulin and TSH receptor (TRAB) antibodies by chemiluminescence. Anti-TPO and anti-TG autoantibody values were higher in Anti-TPO-positive and AntiTG -negative: Type 1 thyroiditis; and in Anti-TPO-negative and AntiTG – positive: Type 2 thyroiditis; and in Anti-TPO-positive and antiTG – positive: Type 3 thyroiditis; and in Anti-TPO-negative and AntiTG –negative: Type 4 thyroiditis. Autoantibody expression was similar in men and women, with predominance of type 4 > type 3 > type 2> type 1 when considering the oldest age of each sex (95 years for women and 85 years for men). When considering the youngest age studied, the following results were obtained: type 2 > type 4 > type 1> type 3 for women and type 3 > type 1 > type 4 > type 2 for men.
Artificial intelligence driven resiliency with machine learning and deep learning components
The future of any business from banking, e-commerce, real estate, homeland security, healthcare, marketing, the stock market, manufacturing, education, retail to government organizations depends on the data and analytics capabilities that are built and scaled. The speed of change in technology in recent years has been a real challenge for all businesses. To manage that, a significant number of organizations are exploring the Big Data (BD) infrastructure that helps them to take advantage of new opportunities while saving costs. Timely transformation of information is also critical for the survivability of an organization. Having the right information at the right time will enhance not only the knowledge of stakeholders within an organization but also providing them with a tool to make the right decision at the right moment. It is no longer enough to rely on a sampling of information about the organizations' customers. The decision-makers need to get vital insights into the customers' actual behavior, which requires enormous volumes of data to be processed. We believe that Big Data infrastructure is the key to successful Artificial Intelligence (AI) deployments and accurate, unbiased real-time insights. Big data solutions have a direct impact and changing the way the organization needs to work with help from AI and its components ML and DL. In this article, we discuss these topics.
Literature review on the relation between tensile strength and flexural strength in isotropic material
The relations between the relation between tensile strength and flexural strength in isotropic material parameters are in isotropic materials to review the relation between tensile strength and flexural strength in isotropic materials and relation between tensile modulus and flexural modulus in isotropic materials. Moreover, the reasons of flexural strength higher than tensile strength in isotropic material are studied. For example, possibilities such as voids and micro aggregations can have more effects on tensile strength than flexural strength are investigated. Within the realm of science, mechanical strength might increase the consequences of composite materials. Moreover, fundamental aspects of tensile strength could relate to this reality that the demerits of isotropic materials and relation to tensile modulus and flexural modulus in isotropic materials pertain. As a tangible example, some scientific research undertaken by the prestigious scholars have asserted that the reasons of flexural strength higher than tensile strength correlated negatively with isotropic material. Hence, it is correct to presume the preconceived notion of isotropic material. Consequently, from an academic stand point, possibilities such as voids and micro aggregations can provide the scientific with some noticeable effects, which related in the fact that merits of effects on tensile strength as well as flexural strength, are inextricably bound up. Nevertheless, according to the literature an academic, the beneficial ramification of both tensile strength and flexural strength in isotropic material parameters apparently can be seen. To conclude, while there are several compelling arguments on both sides. Notwithstanding it can be shown that benefits of voids and micro aggregations far outweigh of its drawbacks. Not only do the advantages prove the significance of flexural strength, but also pinpoint tensile strength implications
Cytotoxicity of novel plant-based silver nanoparticles on fibroblasts for use in dental and medical applications
Background: The aim of this study was to evaluate the cytotoxicity of novel plant-based silver nanoparticles (AgNPs) on mammalian fibroblast cells. Materials and methods: An in vitro prospective, double blind study model was used. A range of 5-17.5 ppm of the novel AgNPs were used in a neutral red uptake cytotoxicity assay. All test samples were compared to a negative and positive control to assess validity. Results: The novel AgNPs showed non-cytotoxicity at all concentrations tested. All tested values were significant compared to the positive controls which showed cytotoxicity (<70% cell viability) via one way anova (p<0.05). Conclusion: The novel AgNPs show promise for use in preventative applications for Dentistry and Medicine. The novel AgNPs could be used as a non-toxic alternative to Chlorhexidine and Cetylpyridinium Chloride
Relationship between migraine and internet addiction in pharmacy students
Background: In recent years, with the rapid popularization of the Internet, lifestyle disturbances, such as insufficient sleep due to excessive use of the Internet, is of concern. Sleep problems are known to trigger migraines. To clarify the relationship between migraine and Internet addiction, a questionnaire survey was conducted for pharmacy students at university. Methods: Internet addiction symptoms were assessed using the Internet Addiction Test (IAT), and migraine was evaluated using modified Japanese migraine screening. Continuous variables were analysed using the unpaired Student’s t-test or one-way analysis of variance followed by multiple Turkey's comparison tests. Categorical variables were analysed by the χ2 test. Results: The recovery rate was 98.9% (442 / 447 students). Of the 288 students who had headaches in the past 3 months, 145 students (32.8%, 145/442 students) were judged as having migraines by migraine screening. Sleep problems (62.1%) were observed in the migraine group. Moreover, sleep deprivation due to headache was noted in 31.7% of the migraine group. The percentage of students with Internet addiction in the migraine group was significantly higher than that in the other headache group or no headache group. Conclusions: Internet addiction was associated with the presence/absence of migraine in pharmacy students at university
Revised phase stability diagram of rare earth sesquioxides
Predictive control and CSTR application based on step response model
Predictive control is a kind of time-domain control method which can display and deal with the control problems of constrained nonlinear systems. It is a new type of computer control algorithm developed in recent years. In the investigation report issued by the International Federation of automatic control in April 19, PID control, system identification, estimation and predictive control after filtering are listed as the most important control technologies, and are considered as the most influential control methods in the future. The inherent robustness of predictive control solves the problem that has puzzled the control theory field for nearly a decade. As soon as it appears, it has been paid attention by the engineering circles at home and abroad, and has been widely and successfully applied in many industrial departments. The current research interests are predictive control, lupon control and the application of predictive control and robust control in electromechanical systems. In the actual industrial production, there is no need for a particularly fine mathematical model, which requires a method that can achieve high quality control effect while the model accuracy is not high First of all, mathematical modelling is needed. The function of prediction model is to predict and control the future output of the system by using the historical information of the controlled object and the assumed future input. Then the optimization algorithm is used for rolling optimization, and the predictive control adopts the finite time domain optimization, which is a kind of repeated online optimization. Last, By detecting the real-time state or output of the current system, the feedback information is used to make the next prediction and optimization closer to the reality before optimizing the control. To avoid the disturbance and system mismatch and other uncertainties, to compensate for the impact of this uncertainty
Preliminary assessment of dry electropolishing technology on a novel additive manufactured Ti- 6Al-4V implant abutment
Unprocessed components fabricated by metal additive manufacturing (AM) tend to be too rough for immediate implementation and require post-processing to allow for proper physical contact, fit and suitability. Utilization of metal AM for the fabrication of dental prostheses requires a smooth finish to prevent the formation of a biofilm and possible inflammatory responses. Standard polishing protocols utilize hand tools and rotary burs to create a mirror polished finish but may not be possible for some small and intricate devices. Dry electropolishing technology (DET) is an automated process for metal AM parts that employs electropolishing by ion transport using free solid bodies, based in a solid media. This preliminary investigation explored dry electropolishing technology on an additive manufactured Ti-6Al-4V implant abutment. The abutments were fabricated with additive manufacturing in dental grade titanium Ti-64 (titanium 6-aluminum 4-vanadium) using Selective Laser Melting (SLM). Components were photographed with a USB microscope at a magnification of 200x, prior to and after DET. The novel dental abutment was evaluated with magnification, a preclinical assessment and evaluation with radiology. DET provided significant polishing of the pin projections, abutment surface and circumference. There was no tactile evidence of thread slippage or excessive play and there were no microgaps detected. The fit seemed clinically acceptable. DET technology seems to provide a simple and predictable post-processing technique that provides surface polishing with Ti-64 dental implant components that cannot be finished by conventional methods.
Successful experience and enlightenment in the prevention of aging and the construction of the Old Age Service System in Japan
Using the methods of literature research, Comparative Analysis, etc. , this paper has discussed the historical process of aging and the similarities and differences between Japan and China. Under the background of the accelerating progress of the population ageing in our country and the increasing number of disabled and semi-disabled elderly, and with reference to the successful experience of Japan in the prevention of aging, this paper has introduced the concrete measures of preventing aging and the construction of advanced and Scientific Social Old-age Service System in Japan. In the light of the current situation of the population ageing in China, learning from the specific measures and successful experience of Japan in the prevention of aging, in order to extend the health years of the elderly in China for more than years and improve their quality of life, it provides the beneficial references for constructing the new social old-age service system.
A retrospective analysis of the effects of CZSG on oral mucositis induced by chemotherapy in patients with malignant tumor
The aim of this study was to quantitatively evaluate the effects of Compound Zhuye Shigao Granule (CZSG) on Oral mucositis (OM) induced by chemotherapy in patients with malignant tumor. The patients in CZSG group started taking CZSG one day before the next chemotherapy cycle (12g each time, 3 times a day for 10 days), the control group without any treatment before chemotherapy. Differences in the incidence and severity of OM between the two groups were examined statistically according to World Health Organization scale for OM. The pain sensation, xerostomia, and taste alteration were evaluated by the Common Terminology Criteria for Adverse Events v3.0 (CTCAE). And the median duration of OM were also recorded between the two groups. There was a significant difference in the OM incidence between the control group and the CZSG group (P<0.01). All the accompanying symptom pain, xerostomia, and taste alteration differed between the two groups (P<0.0001). And the median duration of OM was significantly reduced in the CZSG group as compared to the control group (P<0.0001). Therefore our results show that CZSG has the advantage of rapid onset, good safety and few side effects in the prevention and treatment of OM induced by chemotherapy. .
Green synthesis of biologically active chalcones by Claisen-Schmidt condensation under mild conditions