Potential Clinical Usefulness of CRISPR Cas9 Genome Editing in Cancer Treatment

Authors

  • Marjan Assef University of North Carolina at Greensboro, Greensboro, North Carolina , USA Author
  • Sahar Asvadi Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran, Author
  • Hossein Ghahramani Almanghadim Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran, Author
  • Fatemeh Zeinali Sehrig Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran, Author
  • Zahra Foruzandeh Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran, Author
  • Shahab Masoumi 3 University of California, Berkeley, Berkeley, USA Author
  • Hadis Sheikhi University of North Carolina at Greensboro, Greensboro, North Carolina , USA Author

DOI:

https://doi.org/10.33425/2768-4911.1010

Abstract

Cancer is still considered a main challenge regarding morbidity and mortality, although an earlier diagnosis through screening programs and more effective cure modalities have led to decreased mortality rates so the development of new genetic editing techniques such as zinc finger and TALENs or CRISPRCas9 has enabled the production of strong animal genetic models that sums up the cooperating oncogenic lesions influencing genes with a confirmed role in the proliferation and formation. This review presents the mechanisms of separate genome-editing approaches and explains each of the common nucleasebased platforms.

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Published

2025-07-30

Issue

Vol. 1 No. 2

Section

Articles