The protective role of valsartan in the myocardial injury of diabetic rats induced by herceptin

Abstract

Objective: To evaluate the protective role of valsartan in the myocardial injury of diabetic rats induced by herceptin. Method: 40 Sprague Dawley (SD) rats were randomly divided into control group and treatment group, 20 in each group. All the rats were faded with high sugar and high fat diet in 4 weeks, and then were given streptozotocin (STZ) by intraperitoneal injection in dose of 25mg/kg, fasting blood glucose (FBG) ≥ 16.7mmol/L as a standard of type 2 diabetes model. Two groups were given herceptin by intraperitoneal injection, 12mg/kg in the first day and then 6mg/kg in the following 6 days, but the treatment group was given valsartan by gavage before herceptin injection in dose of 10mg/kg one day, the control group was given the same dose of saline by gavage. The serum BNP were measured, echocardiogram was performed to evaluate the cardiac function before herceptin injection and after 4 weeks. Results: After 4 weeks the BNP, LVEDD, LVESD of the control group were larger than the treatment group, and the EF were smaller, and they were statistically different. Conclusion: Valsartan can alleviate myocardial injury diabetic rats induced by herceptin.