Huangqi-Guizhi-Wuwu Decoction in the Treatment of Diabetic Nephropathy (CKD2-4): A Study Protocol for a Prospective, Open, Multicenter and Controlled Trail

Abstract

Background: In recent years, the disease spectrum has been changing with the change of people's lifestyle. In terms of kidney diseases, the incidence of diabetic nephropathy is increasing year by year and has replaced chronic glomerulonephritis as the primary cause of uremia. Therefore, it is important to delay the progression of renal function in patients with diabetic nephropathy to reduce the occurrence of uremia. Objective: To investigate the efficacy of the treatment of diabetic nephropathy (CKD2-4) with the addition and subtraction of Huangqi-Guizhi-Wuwu Decoction. Method: The 100 patients with diabetic nephropathy were divided into two groups to compare the clinical efficacy. The control group was basic treatment + dapagliflozin, and the observation group was treated with Huangqi-Guizhi-Wuwu Decoction to compare the clinical efficacy, traditional Chinese Medicine (TCM) syndrome integral change, creatinine and urinary protein quantification of the two groups. Expected results: Compared with the dapagliflozin, the addition and subtraction of Huangqi-GuizhiWuwu Decoction can significantly reduce the glomerular filtration rate, lower proteinuria of diabetic nephropathy (CKD2-4) and delay the progression of diabetic nephropathy.